Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth (BDPRS) Study
This study is no longer recruiting participants.
Establishing genetic contributions to the transmission of bipolar disorder (BD) from parents to offspring may inform the risk of developing this disorder and further serve to validate BD in youth. This community-based case-control longitudinal study (Pittsburgh Biological Offspring Study) included parents with BD I/II and their offspring and parents without BD (healthy or non-BD psychopathology) and their offspring in order to evaluate the specific association of BD polygenetic risk scores (PRSs) on the familial transmission and validity of pediatric BD.